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Acetaminophen is comparatively uniformly distributed through most overall body fluids. Binding with the drug to plasma proteins is variable; only 20% to fifty% can be sure with the concentrations encountered through acute intoxication.

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Propoxyphene undergoes intensive very first-move metabolism by intestinal and hepatic enzymes. The key route of metabolism is cytochrome CYP3A4 mediated N-demethylation to norpropoxyphene, that's excreted with the kidneys. Ring hydroxylation and glucuronide formation are minor metabolic pathways.

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The individual could possibly be detoxified by gradual reduction from the dose. Gastrointestinal disturbances or dehydration really should be taken care of with supportive care.

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